Fig. 6
From: Construction of a novel quinoxaline as a new class of Nrf2 activator
Nrf2 activation of TD-1. a The dose–response effect of TD-1 on inhibition of Nrf2/Keap1 interaction. b The 2D-intreraction diagram depicting H-bond, hydrophobic and pi-pi interactions between TD-1 and amino acid residues of the binding pocket of Nrf2/Keap1 interface (PDB ID: 5CGJ). The residues with light green shade denote the amino acids that form hydrophobic interactions with TD-1. c The 3D-interaction diagram showing interaction between TD-1 and key amino acid residues of binding pocket of 5CGJ