Table 7 Toxicity Profile of compounds 2a–2h
Toxicity | 2a | 2b | 2c | 2d | 2e | 2f | 2g | 2h |
|---|---|---|---|---|---|---|---|---|
Nongenotoxic carcinogenicity | No | No | No | No | No | No | No | No |
Genotoxic carcinogenicity | No | No | No | No | No | No | No | Yes |
Invitro mutagenicity alerts (Ames test) | No | No | No | No | No | No | No | No |
Potential for S. typhimurium | No | No | No | No | No | No | No | No |
Max. tolerated dose log (mg/kg/day) | 0.295 | 0.387 | 0.684 | 0.711 | 1.099 | 0.758 | 0.393 | 0.306 |
ORAT (LD50) (mol/kg) | 2.343 | 2.285 | 2.427 | 2.343 | 2.599 | 2.519 | 2.366 | 2.571 |
HT | Yes | No | No | No | No | Yes | No | Yes |
SS | No | No | No | No | No | No | No | No |