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Table 7 Toxicity Profile of compounds 2a2h

From: Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking

Toxicity 2a 2b 2c 2d 2e 2f 2g 2h
Nongenotoxic carcinogenicity No No No No No No No No
Genotoxic carcinogenicity No No No No No No No Yes
Invitro mutagenicity alerts (Ames test) No No No No No No No No
Potential for S. typhimurium No No No No No No No No
Max. tolerated dose log (mg/kg/day) 0.295 0.387 0.684 0.711 1.099 0.758 0.393 0.306
ORAT (LD50) (mol/kg) 2.343 2.285 2.427 2.343 2.599 2.519 2.366 2.571
HT Yes No No No No Yes No Yes
SS No No No No No No No No
  1. HT hepatotoxicity, SS skin sensitization, ORAT oral rat acute toxicity