Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking

Table 1 Physical data of synthesized compounds (1a, 2a–2g)

Comp	Molecular formula	MW calculated (g/mol)	M.P (°C)	Physical state	Color	% Yield	R_f Value
1a	C₆H₈N₂O₂S	172.20	175–177	Solid	Off white-pale yellow	70	0.71
2a	C₁₃H₁₂N₂O₂S	260.31	160–162	Crystal	Light brown	50	0.61
2b	C₁₃H₁₂N₂O₃S	276.31	198–199	Solid	Light brown	56	0.64
2c	C₁₃H₁₂N₂O₃S	276.31	195–197	Solid	Orange	54	0.66
2d	C₁₃H₁₂N₂O₃S	276.31	200–202	Solid	Brown	60	0.69
2e	C₁₄H₁₄N₂O₄S	306.33	196–198	Solid	Light brown	50	0.61
2f	C₁₄H₁₄N₂O₂S	274.33	190–192	Crystal	Light brown	52	0.59
2g	C₁₄H₁₄N₂O₃S	290.33	164–165	Crystal	Light brown	62	0.60

ISSN: 2661-801X