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Table 4 Anticancer screening results of the synthesized compounds

From: Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Compound no. Anticancer screening (IC50 = µM)
Cancer cell lines
HCT116 RAW 264.7
1. 119.26 1.30
2. 93.73 3.36
3. 91.78 1.95
4. 20.27 8.53
5. 12.39 0.82
6. 27.12 5.08
7. 24.31 1.20
8. 99.27 14.36
9. 103.38 15.93
10. 52.28 4.63
11. 114.67 16.38
12. 81.91 3.06
13. 94.14 17.70
14. 87.23 26.67
15. 84.89 17.45
16. 30.09 9.55
17. 14.64 1.74
Raltitrexed (Tomudex) 9.05 2.81
5-Fluorouracil 4.60 0.60