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Table 3 Antimicrobial screening results of the synthesized compounds

From: Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Compound no.

Minimum inhibitory concentration (MIC = µM)

Bacterial strains

Fungal strains

B. subtilis

S. aureus

E. coli

C. albicans

A. niger

1.

91.74

11.47

22.94

11.47

91.74

2.

22.12

88.50

11.06

22.12

11.06

3.

4.81

19.23

9.62

4.81

2.40

4.

22.36

11.18

89.45

11.18

89.45

5.

83.47

10.43

83.47

10.43

20.87

6.

21.19

21.19

21.19

10.59

5.30

7.

21.70

10.85

86.81

10.85

86.81

8.

22.16

11.08

5.54

88.65

11.08

9.

10.59

21.19

84.75

10.59

21.19

10.

11.14

22.28

89.13

89.13

11.14

11.

20.49

2.56

20.49

10.25

81.97

12.

81.97

2.56

81.97

20.49

5.12

13.

11.77

23.54

11.77

23.54

94.16

14.

10.43

20.87

83.47

20.87

83.47

15.

83.33

83.33

10.42

20.83

20.83

16.

86.81

10.85

86.81

10.85

21.70

17.

21.70

86.81

21.70

10.85

21.70

Std.

4.71a

4.71a

4.71a

5.09b

5.09b

DMSO

NA

NA

NA

NA

NA

Broth control

NG

NG

NG

NG

NG

  1. The samples were incubated at 37 ± 1 °C for 24 h (bacteria), at 25 ± 1 °C for 7d (A. niger) and at 37 ± 1 °C for 48 h (C. albicans), respectively and the results were recorded in terms of MIC (the lowest concentration of test substance which inhibited the growth of microorganisms)
  2. Std.: aCiprofloxacin, bFluconazole; NA no activity, NG no growth