Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)- N -(2-(4-chlorophenyl)-4-oxoquinazolin-3(4 H )-yl)acetamide derivatives

BMC Chemistry

Table 3 Antimicrobial screening results of the synthesized compounds

Compound no.	Minimum inhibitory concentration (MIC = µM)
	Bacterial strains			Fungal strains
	B. subtilis	S. aureus	E. coli	C. albicans	A. niger
1.	91.74	11.47	22.94	11.47	91.74
2.	22.12	88.50	11.06	22.12	11.06
3.	4.81	19.23	9.62	4.81	2.40
4.	22.36	11.18	89.45	11.18	89.45
5.	83.47	10.43	83.47	10.43	20.87
6.	21.19	21.19	21.19	10.59	5.30
7.	21.70	10.85	86.81	10.85	86.81
8.	22.16	11.08	5.54	88.65	11.08
9.	10.59	21.19	84.75	10.59	21.19
10.	11.14	22.28	89.13	89.13	11.14
11.	20.49	2.56	20.49	10.25	81.97
12.	81.97	2.56	81.97	20.49	5.12
13.	11.77	23.54	11.77	23.54	94.16
14.	10.43	20.87	83.47	20.87	83.47
15.	83.33	83.33	10.42	20.83	20.83
16.	86.81	10.85	86.81	10.85	21.70
17.	21.70	86.81	21.70	10.85	21.70
Std.	4.71^a	4.71^a	4.71^a	5.09^b	5.09^b
DMSO	NA	NA	NA	NA	NA
Broth control	NG	NG	NG	NG	NG

The samples were incubated at 37 ± 1 °C for 24 h (bacteria), at 25 ± 1 °C for 7d (A. niger) and at 37 ± 1 °C for 48 h (C. albicans), respectively and the results were recorded in terms of MIC (the lowest concentration of test substance which inhibited the growth of microorganisms)
Std.: ^aCiprofloxacin, ^bFluconazole; NA no activity, NG no growth