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Table 1 The physicochemical properties of the synthesized compounds

From: Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Compound no.

M. formula

M. W.

M. P. (°C)

Rf valuea

% yield

1.

C29H29ClN6O3

545.0

150–152

0.51

91.74

2.

C28H26Cl2N6O3

565.5

162–164

0.51

76.90

3.

C29H29ClN6O3

545.0

156–158

0.13

18.24

4.

C30H31ClN6O3

559.1

162–164

0.53

53.03

5.

C28H25Cl3N6O3

599.9

108–110

0.20

69.19

6.

C29H28ClN7O5

590.0

126–128

0.19

81.53

7.

C28H26ClN7O5

576.0

156–158

0.56

92.64

8.

C28H26Cl2N6O3

565.5

128–130

0.43

77.08

9.

C29H28ClN7O5

590.0

138–140

0.15

77.04

10.

C29H29ClN6O4

561.0

156–158

0.50

59.89

11.

C28H26Cl2N6O3

565.5

118–120

0.38

84.18

12.

C28H25Cl2N7O5

610.4

110–112

0.57

77.70

13.

C28H27ClN6O3

531.0

160–162

0.40

74.43

14.

C28H25Cl3N6O3

599.9

120–122

0.29

49.42

15.

C28H25Cl3N6O3

599.9

168–170

0.20

76.90

16.

C28H26ClN7O5

576.0

122–124

0.24

85.78

17.

C28H26ClN7O5

576.0

152–154

0.31

44.61

  1. aTLC mobile phase: benzene