Table 39 Anti-RT and anti-HIV-1 activities, cytotoxicity and selectivity index in MT-4 cells
From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
| Comp. | IC50 (µM) | EC50 (µM) | CC50 (µM) | SI |
|---|---|---|---|---|
| 48a | 0.12 ± 0.035 | 0.04 ± 0.01 | > 221.59 | > 5540 |
| 48b | 0.18 ± 0.018 | 0.06 ± 0.02 | ≥ 235.64 | ≥ 3927 |
| Nevirapine | 2.55 ± 0.93 | 0.19 ± 0.06 | > 15.02 | > 79 |
| Efavirenz | 0.032 ± 0.009 | 0.006 ± 0.0001 | > 1056 | > 6.34 |