Skip to main content

Table 35 Antimycobacterial activity of benzimidazole derivative 41a

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. M. tuberculosis H37Rv
Alamar blue BTG
IC50 (µM) IC90 (µM) MIC (µM) IC50 (µM) IC90 (µM) MIC (µM)
41a 16.14 44.46 100 11.52 16.53 50
Amikacin 0.12 0.14 0.16 0.07 0.12 0.16
Cycloserine 24.76 28.01 100 23.55 26.38 100
Ethambutol 3.45 > 200 NA 1.50 1.64 6.25
Isoniazid 0.19 > 5 NA 0.13 0.20 0.31
Pyrimethamine 25.09 28.00 100 24.27 46.37 100
Rifampicin 0.02 0.02 0.16 0.02 0.03 0.04