Table 35 Antimycobacterial activity of benzimidazole derivative 41a
From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
| Comp. | M. tuberculosis H37Rv | |||||
|---|---|---|---|---|---|---|
| Alamar blue | BTG | |||||
| IC50 (µM) | IC90 (µM) | MIC (µM) | IC50 (µM) | IC90 (µM) | MIC (µM) | |
| 41a | 16.14 | 44.46 | 100 | 11.52 | 16.53 | 50 |
| Amikacin | 0.12 | 0.14 | 0.16 | 0.07 | 0.12 | 0.16 |
| Cycloserine | 24.76 | 28.01 | 100 | 23.55 | 26.38 | 100 |
| Ethambutol | 3.45 | > 200 | NA | 1.50 | 1.64 | 6.25 |
| Isoniazid | 0.19 | > 5 | NA | 0.13 | 0.20 | 0.31 |
| Pyrimethamine | 25.09 | 28.00 | 100 | 24.27 | 46.37 | 100 |
| Rifampicin | 0.02 | 0.02 | 0.16 | 0.02 | 0.03 | 0.04 |