Table 3 In vitro trypanocidal activity of synthesized compound 4a
From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
Comp. | Trypanosoma cruzi | ||||
|---|---|---|---|---|---|
LC50 (mM) | CC50 (mM) | Selectivity index (SI) | |||
INC5 | NINOA | INC5 | NINOA | ||
4a | 0.32 | 0.014 | 43.2 | 135 | 3085.71 |
Nifurtimox | 0.69 | 0.78 | 25.4 | 36.81 | 32.56 |
Benznidazole | 0.31 | 0.60 | 23.6 | 76.13 | 39.3 |