Table 26 Inhibitory effect on COX-2 and COX-1 activity in human whole blood assay
From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
| Comp. | COX-2 IC50 µM | COX-1 IC50 µM | COX-1/COX-2 |
|---|---|---|---|
| 22a | 1 | 384 | 384 |
| 22b | 1.06 | > 500 | > 470 |
| Rofecoxib | 0.057 | 11.4 | 200 |