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Table 26 Inhibitory effect on COX-2 and COX-1 activity in human whole blood assay

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. COX-2 IC50 µM COX-1 IC50 µM COX-1/COX-2
22a 1 384 384
22b 1.06 > 500 > 470
Rofecoxib 0.057 11.4 200