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Table 25 Anti-inflammatory activities of benzimidazole compounds 21a-c by carrageenan-induced rat paws edema method

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp.

(Mean ± SEM) tail withdrawing time in second

Inhibition (%)

0 h

1 h

2 h

3 h

4 h

4 h

Control (0.5% CMC)

0.14 ± 0.01

0.23 ± 0.01

0.24 ± 0.02

0.25 ± 0.01

0.25 ± 0.01

–

Pentazocine

0.14 ± 0.01

0.12 ± 0.01

0.12 ± 0.01

0.10 ± 0.01

0.09 ± 0.01

64

21a

0.14 ± 0.02

0.12 ± 0.02

0.11 ± 0.01

0.11 ± 0.02

0.10 ± 0.01

60

21b

0.15 ± 0.02

0.15 ± 0.01

0.13 ± 0.01

0.13 ± 0.01

0.10 ± 0.01

60

21c

0.14 ± 0.01

0.13 ± 0.01

0.12 ± 0.01

0.10 ± 0.11

0.09 ± 0.02

64