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Table 25 Anti-inflammatory activities of benzimidazole compounds 21a-c by carrageenan-induced rat paws edema method

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. (Mean ± SEM) tail withdrawing time in second Inhibition (%)
0 h 1 h 2 h 3 h 4 h 4 h
Control (0.5% CMC) 0.14 ± 0.01 0.23 ± 0.01 0.24 ± 0.02 0.25 ± 0.01 0.25 ± 0.01
Pentazocine 0.14 ± 0.01 0.12 ± 0.01 0.12 ± 0.01 0.10 ± 0.01 0.09 ± 0.01 64
21a 0.14 ± 0.02 0.12 ± 0.02 0.11 ± 0.01 0.11 ± 0.02 0.10 ± 0.01 60
21b 0.15 ± 0.02 0.15 ± 0.01 0.13 ± 0.01 0.13 ± 0.01 0.10 ± 0.01 60
21c 0.14 ± 0.01 0.13 ± 0.01 0.12 ± 0.01 0.10 ± 0.11 0.09 ± 0.02 64