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Table 3 Docking analysis of some imidazole derivatives and the reference drug Fluconazole against Saccharomyces cerevisiae CYP51

From: Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

Compound

ΔGbinding (kcal/mol)

H-bond

Distance (Å)

2

− 6.857

N(3)-Cys470

2.31

10

− 6.791

N(3)-Arg489

2.41

6

− 5.616

–

–

30

–

–

–

Fluconazole

− 7.337

N(4)-Arg467

2.70

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BMC Chemistry

ISSN: 2661-801X

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