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Table 3 Docking analysis of some imidazole derivatives and the reference drug Fluconazole against Saccharomyces cerevisiae CYP51

From: Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

Compound ΔGbinding (kcal/mol) H-bond Distance (Å)
2 − 6.857 N(3)-Cys470 2.31
10 − 6.791 N(3)-Arg489 2.41
6 − 5.616
30
Fluconazole − 7.337 N(4)-Arg467 2.70