Table 4 The pharmacokinetic parameters of flibanserin in rat plasma after oral administration
Parameters | Unit | Mean po 10 mg/kg | SD | RSD/% |
|---|---|---|---|---|
AUC(0–t) | μg/L h | 351,658.00 | 77,499.85 | 22.0 |
AUC(0–∞) | μg/L h | 356,517.60 | 77,670.82 | 21.8 |
MRT(0–t) | h | 2.70 | 0.29 | 10.7 |
MRT(0–∞) | h | 2.88 | 0.29 | 10.2 |
t1/2z | h | 2.03 | 0.66 | 32.7 |
Tmax | h | 0.79 | 0.19 | 23.7 |
Vz/F | L/kg | 0.09 | 0.04 | 42.5 |
CLz/F | L/h/kg | 0.03 | 0.01 | 27.6 |
Cmax | μg/L | 108,224.40 | 25,506.58 | 23.6 |