Skip to main content

Advertisement

Table 4 The pharmacokinetic parameters of flibanserin in rat plasma after oral administration

From: A rapid and sensitive UPLC-MS/MS method for the determination of flibanserin in rat plasma: application to a pharmacokinetic study

Parameters Unit Mean po 10 mg/kg SD RSD/%
AUC(0–t) μg/L h 351,658.00 77,499.85 22.0
AUC(0–∞) μg/L h 356,517.60 77,670.82 21.8
MRT(0–t) h 2.70 0.29 10.7
MRT(0–∞) h 2.88 0.29 10.2
t1/2z h 2.03 0.66 32.7
Tmax h 0.79 0.19 23.7
Vz/F L/kg 0.09 0.04 42.5
CLz/F L/h/kg 0.03 0.01 27.6
Cmax μg/L 108,224.40 25,506.58 23.6