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Table 3 Determination of PAR and IBU in pharmaceutical preparation and application of standard addition technique

From: Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form

(A) Market preparation: Cetafen® tablet claimed to contain 325 mg PAR and 200 mg IBU
Proposed method recovery %a Standard addition technique
Ratio difference
Ratio difference Mean centering Constant center Taken (μg/mL) Recovery %a
PAR IBU PAR IBU PAR IBU PAR IBU PAR IBU
100.12 ± 0.62 101.34 ± 1.51 99.58 ± 0.53 100.52 ± 1.26 99.68 ± 0.95 100.44 ± 1.17 3.0 20.0 100.76 99.16
3.0 20.0 101.53 100.34
3.0 20.0 100.42 101.95
Standard addition technique
Mean centering Constant center
Taken (μg/mL) Recovery %a Taken (μg/mL) Recovery %a
PAR IBU PAR IBU PAR IBU PAR IBU
3.0 20.0 98.14 100.96 3.0 20.0 100.37 99.02
3.0 20.0 100.33 100.55 3.0 20.0 98.43 100.55
3.0 20.0 101.08 101.13 3.0 20.0 100.85 99.89
(B) Market preparation: Parofen® tablet claimed to contain 500 mg PAR and 400 mg IBU
Proposed method recovery %a Standard addition technique
Ratio difference
Ratio difference Mean centering Constant center Taken (μg/mL) Recovery %a
PAR IBU PAR IBU PAR IBU PAR IBU PAR IBU
98.72 ± 0.89 100.74 ± 0.56 100.58 ± 0.93 101.22 ± 1.18 9936 ± 0.52 100.36 ± 1.03 3.0 20.0 100.54 99.96
3.0 20.0 101.24 101.31
3.0 20.0 101.43 100.63
Standard addition technique
Mean centering Constant center
Taken (μg/mL) Recovery %a Taken (μg/mL) Recovery %a
PAR IBU PAR IBU PAR IBU PAR IBU
3.0 20.0 100.73 100.13 3.0 20.0 101.33 99.45
3.0 20.0 101.12 99.58 3.0 20.0 100.95 99.82
3.0 20.0 100.37 100.22 3.0 20.0 100.04 98.73
  1. aAverage of three separate determinations