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Table 1 Logarithm of the retention factor (log k) on C18 column using methanol–water system (60–80% are percentages of methanol in the mobile phase)

From: Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC

Compound Log k
60% 65% 70% 75% 80%
11a 0.088 0.041 − 0.206 − 0.412 − 0.695
11b 0.317 0.493 − 0.016 − 0.235 − 0.607
11c 0.635 0.501 0.123 − 0.036 − 0.145
11d a 0.901 0.364 0.123 − 0.041
16a 0.130 0.053 − 0.220 − 0.424 − 0.385
16b 0.481 0.280 0.150 − 0.233 − 0.198
17a 0.950 0.824 0.740 − 0.12 − 0.051
17b 0.847 0.743 0.611 − 0.221 − 0.410
Celecoxib a 0.950 0.83 0.530 0.235
  1. aCompound retained on the stationary phase