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Table 1 Antimicrobial activity of newly synthesized compounds

From: Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Comp. no.

Gram (+ve) bacteria

Gram (−ve) bacteria

Fungi

S. aureus

B. subtilis

E. coli

P. vulgaris

A. fumigatus

C. albicans

5a

20

22

20

10

5b

18

15

16

12

5c

19

24

23

14

5d

22

20

19

16

5e

23

19

15

17

5f

21

24

14

16

5g

20

25

14

18

5h

26

20

21

20

25

5i

12

11

15

13

5j

15

17

12

5k

15

12

17

15

5l

14

25

14

10

5m

16

18

16

11

5n

15

22

14

10

17

11

5o

13

21

16

5p

19

23

20

14

30

13

6a

17

22

15

19

30

22

6b

16

12

13

14

21

15

6c

15

14

16

13

20

14

6d

13

17

15

16

17

22

6e

12

15

12

15

15

14

6f

13

15

13

16

19

12

6g

6h

20

17

18

19

20

22

6i

14

20

15

12

35

15

6j

18

16

13

15

33

6k

16

23

17

14

33

23

6l

20

25

20

16

32

26

6m

17

19

12

13

27

12

6n

16

25

14

25

30

14

6o

6p

20

22

20

17

38

15

Sta

24

26

30

25

17

20

  1. Mean zone of inhibition in mm ± standard deviation (S.D.)
  2. No activity
  3. aReference controls for the microorganisms are “Gentamycin” (for the Gram +ve and Gram −ve bacteria), and “Ketoconazol” for Fungi