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Table 1 Antimicrobial activity of newly synthesized compounds

From: Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Comp. no. Gram (+ve) bacteria Gram (−ve) bacteria Fungi
S. aureus B. subtilis E. coli P. vulgaris A. fumigatus C. albicans
5a 20 22 20 10
5b 18 15 16 12
5c 19 24 23 14
5d 22 20 19 16
5e 23 19 15 17
5f 21 24 14 16
5g 20 25 14 18
5h 26 20 21 20 25
5i 12 11 15 13
5j 15 17 12
5k 15 12 17 15
5l 14 25 14 10
5m 16 18 16 11
5n 15 22 14 10 17 11
5o 13 21 16
5p 19 23 20 14 30 13
6a 17 22 15 19 30 22
6b 16 12 13 14 21 15
6c 15 14 16 13 20 14
6d 13 17 15 16 17 22
6e 12 15 12 15 15 14
6f 13 15 13 16 19 12
6g
6h 20 17 18 19 20 22
6i 14 20 15 12 35 15
6j 18 16 13 15 33
6k 16 23 17 14 33 23
6l 20 25 20 16 32 26
6m 17 19 12 13 27 12
6n 16 25 14 25 30 14
6o
6p 20 22 20 17 38 15
Sta 24 26 30 25 17 20
  1. Mean zone of inhibition in mm ± standard deviation (S.D.)
  2. No activity
  3. aReference controls for the microorganisms are “Gentamycin” (for the Gram +ve and Gram −ve bacteria), and “Ketoconazol” for Fungi