Table 4 Antiproliferative activity of synthesized pyrimidine derivatives
Anticancer activity (IC50 = µM) | |||
|---|---|---|---|
Comp. | Cancer cell (HCT116) | Comp. | Cancer cell (HCT116) |
Ax1 | 48.4 | Ax11 | 3.0 |
Ax2 | 2.70 | Ax12 | 111.3 |
Ax3 | 61.7 | Ax13 | 15.1 |
Ax4 | 42.3 | Ax14 | 69.6 |
Ax5 | 31.5 | Ax15 | 94.7 |
Ax6 | 43.7 | Ax16 | 13.9 |
Ax7 | 1.90 | Ax17 | 75.3 |
Ax8 | 2.20 | Ax18 | 3.60 |
Ax9 | 16.7 | Ax19 | 12.4 |
Ax10 | 0.80 | Â | Â |
5-fluorouracil | 6.20 | Â | Â |