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Table 4 Results of stability tests under different conditions for the determination of metformin and canagliflozin QC samples by the proposed LC–MS/MS method

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

 

Canagliflozin

Metformin

Spiked conc.

(ng/mL)

Mean found

(ng/mL)

Accuracy%

RSD%

spiked conc. (ng/mL)

Mean found

(ng/mL)

Accuracy%

RSD%

Short term stability

30

26.30

87.67

1.90

150

132.38

88.25

1.69

800

704.72

88.09

2.66

4000

3565.06

89.13

2.57

Freeze and thaw stability

30

28.61

95.37

6.36

150

141.10

94.07

3.76

800

713.42

89.18

3.52

4000

3552.69

88.82

2.29

Dry extract stability

30

28.54

95.13

4.54

150

139.01

92.67

7.34

800

696.46

87.06

1.20

4000

3699.81

92.50

3.26

Processed sample stability

30

28.12

93.73

3.11

150

134.03

89.35

1.70

800

698.63

87.33

0.61

4000

3836.46

95.91

6.01

Long term stability

30

29.77

99.23

7.73

150

130.4

86.93

1.87

800

687.82

85.98

0.83

4000

3619.81

90.50

4.63

  1. Mean, accuracy% and RSD% were calculated using three determinations