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Table 4 Results of stability tests under different conditions for the determination of metformin and canagliflozin QC samples by the proposed LC–MS/MS method

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

  Canagliflozin Metformin
Spiked conc.
(ng/mL)
Mean found
(ng/mL)
Accuracy% RSD% spiked conc. (ng/mL) Mean found
(ng/mL)
Accuracy% RSD%
Short term stability 30 26.30 87.67 1.90 150 132.38 88.25 1.69
800 704.72 88.09 2.66 4000 3565.06 89.13 2.57
Freeze and thaw stability 30 28.61 95.37 6.36 150 141.10 94.07 3.76
800 713.42 89.18 3.52 4000 3552.69 88.82 2.29
Dry extract stability 30 28.54 95.13 4.54 150 139.01 92.67 7.34
800 696.46 87.06 1.20 4000 3699.81 92.50 3.26
Processed sample stability 30 28.12 93.73 3.11 150 134.03 89.35 1.70
800 698.63 87.33 0.61 4000 3836.46 95.91 6.01
Long term stability 30 29.77 99.23 7.73 150 130.4 86.93 1.87
800 687.82 85.98 0.83 4000 3619.81 90.50 4.63
  1. Mean, accuracy% and RSD% were calculated using three determinations