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Table 2 Intra-day and inter-day precision and accuracy for the determination of metformin and canagliflozin in human plasma

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

Studied drug QC level Intra-day, n = 6 Inter-day, n = 6 × 3
Mean conc.
found (ng/ml)
Accuracy% RSD% Mean conc.
found (ng/ml)
Accuracy% RSD%
Metformin LLOQ (50 ng/mL) 47.24 94.48 7.301 48.55 97.10 8.275
LQC (150 ng/mL) 152.17 101.45 2.980 161.15 107.43 4.980
MQC (1000 ng/mL) 943.81 94.38 8.465 935.77 93.58 6.347
HQC (4000 ng/mL) 3667.95 91.70 4.114 3734.26 93.36 6.626
Canagliflozin LLOQ (10 ng/mL) 11.31 113.10 1.921 11.12 111.20 4.528
LQC (30 ng/mL) 32.73 109.10 2.173 29.95 99.83 10.244
MQC (200 ng/mL) 181.30 90.65 7.085 176.28 88.14 4.664
HQC (800 ng/mL) 768.06 96.01 6.023 738.32 92.29 6.644
  1. n = 3 days, 6 replicates per day