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Table 5 Statistical comparison of the results obtained by the proposed methods and reference methods for the determination of PAR, PSE and BRM

From: Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

  PAR Ref. [29] PSE Ref. [29] BRM Ref. [26]
TLC HPLC UPLC TLC HPLC UPLC TLC HPLC UPLC
Mean 99.46 100.67 99.55 99.40 99.74 99.02 98.99 100.11 100.02 100.32 98.28 99.12
SD 1.569 1.430 1.270 0.778 1.090 1.171 1.11 0.427 0.735 1.521 0.910 0.699
N 6 6 6 4 6 6 6 4 6 6 6 4
Variance 2.462 2.045 1.613 0.605 1.188 1.371 1.232 0.182 0.540 2.310 0.828 0.489
Student’s t 0.080 (2.310) 1.611 (2.310) 0.374 (2.310)   0.640 (2.310) 1.762 (2.310) 1.870 (2.310)   1.920 (2.310) 1.464 (2.310) 1.586 (2.310)  
F 4.07 (9.01) 3.38 (9.01) 2.67 (9.01) 6.53 (9.01) 7.52 (9.01) 6.77 (9.01) 1.10 (9.01) 4.72 (9.01) 1.69 (9.01)
  1. Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05
  2. Reported method for determination of PAR and PSE is an HPLC method using C18 column, a mobile phase composed of 25 mM phosphate buffer (pH = 5):methanol:acetonitrile (30:60:10, v/v/v) at flow rate 1 mL/min and detection at 240 nm
  3. Reported method for determination of BRM is a TLC using methanol:ammonia (100:1.5 v/v) as mobile phase