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Table 2 Analysis of laboratory prepared mixtures by the proposed chromatographic methods

From: Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

Mix TLC HPLC–UV UPLC-MS/MS
Concentration Recovery %a Concentration Recovery %a Concentration Recovery %a
PAR PSE BRM PAR PSE BRM PAR PSE BRM PAR PSE BRM PAR PSE BRM PAR PSE BRM
1 6.0 5.0 0.8 98.54 99.80 102.53 100.0 30.0 100.0 101.09 101.46 100.29 40.0 20.0 20.0 98.44 99.13 99.96
2 2.5 10.0 0.4 98.00 99.70 99.25 50.0 100.0 50.0 99.66 101.30 101.64 400.0 50.0 50.0 100.81 98.97 101.52
3 2.5 2.5 0.2 98.80 98.80 101.00 50.0 50.0 50.0 102.55 98.53 101.99 120.0 100.0 200.0 99.93 101.20 101.99
4 12.5 2.5 0.2 99.20 98.00 102.00 100.0 150.0 100.0 99.75 102.32 98.88 700.0 200.0 300.0 98.52 100.53 98.56
5b 24.0 1.44 0.3c 101.88 100.00 102.33d 50.0 33.0c 30.2c 100.41 99.95 99.63 1000.0 60.0 4.0 100.10 100.45 99.80
6 7.5 10.0 0.4 99.60 99.10 99.50 100.0 100.0 50.0 101.73 102.25 99.51 100.0 100.0 100.0 99.89 98.97 101.52
Mean ± SD   99.30 ± 1.484 99.23 ± 0.755 101.03 ± 1.470   100.87 ± 1.143 100.97 ± 1.470 100.33 ± 1.390   98.85 ± 0.831 100.02 ± 1.001 100.56 ± 1.328
  1. aAverage of three determinations
  2. bRatio present in dosage form
  3. cAmount spiked was 0.204 µg/band of BRM for the TLC method and was 30.00 µg/mL of PSE and BRM for HPLC method
  4. dAfter spiking and subtraction of the added standard