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Table 2 Analysis of laboratory prepared mixtures by the proposed chromatographic methods

From: Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

Mix

TLC

HPLC–UV

UPLC-MS/MS

Concentration

Recovery %a

Concentration

Recovery %a

Concentration

Recovery %a

PAR

PSE

BRM

PAR

PSE

BRM

PAR

PSE

BRM

PAR

PSE

BRM

PAR

PSE

BRM

PAR

PSE

BRM

1

6.0

5.0

0.8

98.54

99.80

102.53

100.0

30.0

100.0

101.09

101.46

100.29

40.0

20.0

20.0

98.44

99.13

99.96

2

2.5

10.0

0.4

98.00

99.70

99.25

50.0

100.0

50.0

99.66

101.30

101.64

400.0

50.0

50.0

100.81

98.97

101.52

3

2.5

2.5

0.2

98.80

98.80

101.00

50.0

50.0

50.0

102.55

98.53

101.99

120.0

100.0

200.0

99.93

101.20

101.99

4

12.5

2.5

0.2

99.20

98.00

102.00

100.0

150.0

100.0

99.75

102.32

98.88

700.0

200.0

300.0

98.52

100.53

98.56

5b

24.0

1.44

0.3c

101.88

100.00

102.33d

50.0

33.0c

30.2c

100.41

99.95

99.63

1000.0

60.0

4.0

100.10

100.45

99.80

6

7.5

10.0

0.4

99.60

99.10

99.50

100.0

100.0

50.0

101.73

102.25

99.51

100.0

100.0

100.0

99.89

98.97

101.52

Mean ± SD

 

99.30 ± 1.484

99.23 ± 0.755

101.03 ± 1.470

 

100.87 ± 1.143

100.97 ± 1.470

100.33 ± 1.390

 

98.85 ± 0.831

100.02 ± 1.001

100.56 ± 1.328

  1. aAverage of three determinations
  2. bRatio present in dosage form
  3. cAmount spiked was 0.204 µg/band of BRM for the TLC method and was 30.00 µg/mL of PSE and BRM for HPLC method
  4. dAfter spiking and subtraction of the added standard