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Table 3 Precision data of determination of the FF and GLY in pure form using (A) spectrophotometric method and (B) IPC method

From: Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

(A) Spectrophotometric method
Derivative spectrophotometric method FF Conc208.27nm (μg/mL) GLY Conc239.6nm (μg/mL)
4.8 6.0 7.2 6.75 9.0 11.25
Intra-day
 \({\bar{\text{X}}}\) 100.14 99.80 100.03 100.13 99.21 100.33
 ± SD 0.29 0.61 0.68 0.29 0.20 0.75
 % RSD 0.29 0.61 0.68 0.29 0.20 0.75
 % Error 0.17 0.35 0.39 0.17 0.12 0.43
Inter-day
 \({\bar{\text{X}}}\) 100.12 100.24 99.86 100.14 99.60 100.12
 ± SD 0.21 0.52 0.95 0.75 0.42 0.55
 % RSD 0.21 0.52 0.95 0.74 0.42 0.55
 % Error 0.12 0.30 0.55 0.43 0.24 0.32
Ratio derivative spectrophotometric method FF Conc214/229nm (μg/mL) GLY Conc240/259nm (μg/mL)
4.8 6.0 7.2 6.75 9.0 11.25
Intra-day
 \({\bar{\text{X}}}\) 99.89 100.07 99.82 100.64 100.74 99.91
 ± SD 0.58 0.85 0.49 0.36 0.29 0.64
 % RSD 0.58 0.85 0.49 0.36 0.29 0.64
 % Error 0.33 0.49 0.28 0.21 0.17 0.37
Inter-day
 \({\bar{\text{X}}}\) 100.53 100.08 100.43 99.82 99.44 100.47
 ± SD 0.23 0.54 0.75 0.96 0.13 0.76
 % RSD 0.23 0.54 0.74 0.96 0.13 0.75
 % Error 0.13 0.31 0.43 0.55 0.07 0.44
(B) IPC method
IPC method FF Conc. (μg/mL) GLY Conc. (μg/mL)
0.6 1.2 1.8 1.125 2.25 3.375
Intra-day
 \({\bar{\text{X}}}\) 100.89 99.41 99.45 100.03 99.54 99.24
 ± SD 0.67 0.41 0.66 0.60 0.66 0.35
 % RSD 0.66 0.41 0.66 0.60 0.67 0.35
 % Error 0.38 0.24 0.38 0.35 0.39 0.20
Inter-day
 \({\bar{\text{X}}}\) 99.84 99.60 99.48 99.95 100.58 99.66
 ± SD 0.44 0.37 0.60 0.53 0.62 0.45
 % RSD 0.44 0.37 0.61 0.53 0.61 0.45
 % Error 0.23 0.21 0.35 0.30 0.38 0.26