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Table 5 Docking results of most active anticancer compound p2 with standard drug

From: 4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile

Compound

Docking score

Glide energy (kcal/mol)

Interactive residues

p2

− 6.732

− 42.44

Trp383, Leu384, Leu387, Met388, Leu391, Phe404, Met343, Leu346, Met347

5-Fluorouracil

− 3.414

− 24.58

Glu353, Ala350, Leu349, Leu346, Leu348, Leu387, Met388, Phe404, Leu391, Arg394