Table 3 Antimicrobial and anticancer screening results of synthesized thiazole molecules (p1–p10)
Compound | (Antimicrobial screening) MIC = µM | aIC50 = µM | ||||
|---|---|---|---|---|---|---|
Microbial species | ||||||
Bacterial | Fungal | Cancer cell line | ||||
S.A. | B.S. | E.C. | C.A. | A.N. | MCF7 | |
p1 | 31 | 62.0 | 31 | 31 | 31 | 17.4 |
p2 | 16.1 | 32.1 | 16.1 | 32.1 | 32.1 | 10.5 |
p3 | 32.4 | 32.4 | 32.4 | 32.4 | 16.2 | 37.4 |
p4 | 28.8 | 28.8 | 28.8 | 28.8 | 28.8 | 38.0 |
p5 | 29.6 | 29.6 | 29.6 | 29.6 | 29.6 | 40.3 |
p6 | 30.5 | 30.5 | 30.5 | 15.3 | 30.5 | 73.3 |
p7 | 33.1 | 33.1 | 33.1 | 16.5 | 33.1 | 47.6 |
p8 | 31 | 31.0 | 62.0 | 15.5 | 62.0 | 52.1 |
p9 | 33.5 | 67.0 | 67.0 | 33.5 | 33.5 | 17.2 |
p10 | 17.4 | 34.8 | 34.8 | 34.8 | 34.8 | 21.4 |
Norfloxacin | 4.7 | 4.7 | 4.7 | – | – | – |
Fluconazole | – | – | – | 5.0 | 5.0 | – |
5-Fluorouracil | – | – | – | – | – | 5.2 |