A-549
|
Molar drug concentrations calculated from graph
|
---|
LC50
|
TGI
|
GI50*
|
---|
S6
|
NE
|
NE
|
0.048
|
S7
|
NE
|
NE
|
0.359
|
S
8
|
19.5
|
0.126
|
8E−04
|
S9
|
NE
|
36.2
|
0.014
|
S10
|
40.84
|
0.222
|
0.001
|
ADR
|
0.199
|
2E−05
|
2E−09
|
- Obs. the minimum drug concentration which causes 50% inhibition of cell growth (GI50) in last column is showed in italics
- Where GI50 value of ≤ 10−6 molar (i.e. 1 µmolar) or ≤ 10 µg/ml is considered to demonstrate activity in case of pure compounds. For extracts, GI50 value ≤ 20 µg/ml is found to demonstrate activity
- LC50: drug concentration which cause 50% cell kill; GI50: drug concentration which cause 50% inhibition of cell growth; TGI: drug concentration which cause total inhibition of cell growth; ADR: adriamycin, positive control compound