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Table 6 Anticancer activity of selected newly synthesized derivatives

From: Synthesis of thiophene derivatives and their anti-microbial, antioxidant, anticorrosion and anticancer activity

A-549

Molar drug concentrations calculated from graph

LC50

TGI

GI50*

S6

NE

NE

0.048

S7

NE

NE

0.359

S 8

19.5

0.126

8E−04

S9

NE

36.2

0.014

S10

40.84

0.222

0.001

ADR

0.199

2E−05

2E−09

  1. Obs. the minimum drug concentration which causes 50% inhibition of cell growth (GI50) in last column is showed in italics
  2. Where GI50 value of ≤ 10−6 molar (i.e. 1 µmolar) or ≤ 10 µg/ml is considered to demonstrate activity in case of pure compounds. For extracts, GI50 value ≤ 20 µg/ml is found to demonstrate activity
  3. LC50: drug concentration which cause 50% cell kill; GI50: drug concentration which cause 50% inhibition of cell growth; TGI: drug concentration which cause total inhibition of cell growth; ADR: adriamycin, positive control compound
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BMC Chemistry

ISSN: 2661-801X

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