Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China

Table 3 NO inhibitory activity of the new compounds (1–3) from aerial part of Tirpitzia sinensis

Compound	Dose (μM)	NO inhibition rate (%)	IC ^a₅₀ (μM)
1	0.1	0	14.97 ± 0.87
	1	11.97 ± 0.41
	10	36.47 ± 2.37
2	0.1	0	26.63 ± 1.32
	1	7.40 ± 1.68
	10	20.10 ± 0.43
3	0.1	3.93 ± 0.57	17.09 ± 2.3
	1	18.04 ± 1.93
	10	23.33 ± 2.42

^aThe concentrations of compounds that gave 50% inhibiting potential was calculated by modified Kou type equation: lgIC₅₀ = X_m − I(P − (3 − P_m − P_n)/4). Positive control (curcumin) gave an IC₅₀ value of 4.75 μΜ

ISSN: 2661-801X