Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China

Table 2 Target fishing results of the new compounds (1–3) isolated from Tirpitzia sinensis

Compound	Pharma-ID	Fit value	Gene-name	Uniprot-AC	KEGG-identify	Target-class	Target-class A
1	3pp0	0.506772	ERBB2_HUMAN	P04626	K05083	Receptor tyr kinase	ERBB2
2	2nry	0.858086	IRAK4_HUMAN	Q9NWZ3	K04733	Interleukin-1 receptors	IRAK4
	3ac3	0.798580	LCK_HUMAN	P06239	K05856	Tyr protein kinases	LCK
	3io7	0.769459	JAK2_HUMAN	O60674	K04447	Tyr protein kinases	JAK2
3	3zya	0.916562	MK14_HUMAN	Q16539	K04441	Ser/Thr protein kinases	MAPK14
	3ehx	0.816364	MMP12_HUMAN	P39900	K01413	Zinc-dependent endopeptidases	MMP-12

ERBB2 means receptor tyrosine-protein kinase erbB-2; IRAK4 means interleukin-1 receptor-associated kinase 4; LCK means lymphocyte specific kinase; JAK2 means Janus kinase 2; MAPK14 means mitogen-activated protein kinase 14; MMP-12 means matrix metalloproteinase 12

ISSN: 2661-801X