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Table 3 Antimicrobial screening results of synthesized derivatives

From: Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents

Comp. Minimum inhibitory concentration (MIC = µM)
Bacterial strains Fungal strains
SA
MTCC3160
ST
MTCC3231
KP
MTCC9024
EC
MTCC443
AN
MTCC281
CA
MTCC227
Z1 33.49 66.97 16.74 33.49 4.18 16.74
Z2 76.13 38.06 38.06 76.13 38.06 19.03
Z3 38.06 76.13 19.03 38.06 38.06 19.03
Z4 69.02 69.02 34.51 69.02 17.26 34.51
Z5 69.02 34.51 34.51 69.02 17.26 34.51
Z6 68.91 68.91 34.45 68.91 34.45 4.31
Z7 78.67 78.67 19.67 39.33 19.67 39.33
Z8 78.67 39.33 39.33 78.67 19.67 4.92
Z9 80.28 80.28 40.14 80.28 20.07 40.14
Z10 34.45 68.91 17.23 34.45 34.45 68.91
Z11 82.97 41.49 41.49 20.74 41.49 5.18
Z12 41.49 82.97 20.74 20.74 5.18 20.74
Z13 42.03 84.06 42.03 42.03 5.25 21.02
Z14 80.28 40.14 40.14 20.07 40.14 20.07
Z15 84.06 42.03 42.03 21.02 42.03 5.25
Z16 35.17 70.34 35.17 70.34 35.17 17.59
Z17 70.34 35.17 35.17 70.34 17.59 35.17
Z18 70.34 70.34 17.59 70.34 17.59 35.17
Z19 35.07 70.15 35.07 70.15 17.54 35.07
Z20 33.75 67.49 16.87 33.75 33.75 67.49
Z21 32.11 64.22 32.11 32.11 4.01 16.05
Z22 76.59 38.30 76.59 38.30 38.30 19.15
Z23 33.75 67.49 16.87 67.49 16.87 67.49
Z24 30.10 30.10 15.05 15.05 3.76 3.76
Z25 65.21 65.21 32.60 32.60 16.30 32.60
Z26 35.37 70.74 17.69 35.37 17.69 4.42
Z27 65.91 65.91 16.48 65.91 16.48 32.96
Z28 36.25 72.51 18.13 72.51 7.25 18.13
Z29 37.16 74.32 18.58 74.32 18.58 37.16
Z30 36.72 73.44 73.44 18.36 36.72 18.36
DMSO NA NA NA NA NA NA
Broth control NG NG NG NG NG NG
Std. 34.40a 34.40a 17.20a 17.20a 10.20b 10.20b
  1. SA, Staphylococcus aureus; ST, Salmonella typhi; KP, Klebsiella pneumoniae; EC, Escherichia coli; CA, Candida albicans; AN, Aspergillus niger; DMSO, Dimethyl sulfoxide; NA, No activity; NG, No growth
  2. Std drugs: aCefadroxil; bFluconazole