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Table 1 The physicochemical properties of synthesized benzimidazole derivatives

From: Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents

Comp. IUPAC name Mol. structure Mol. formula Rf valuea m. p. (oC) % yield
Z1 1H-Benzo[d]imidazol-2-yl 2-(2,4-dinitrophenyl-amino) ethanethioate C15H11N5O5S 0.48 180–183 83.64
Z2 1H-Benzo[d]imidazol-2-yl 2-(2-nitrophenylamino)ethanethioate C15H12N4O3S 0.82 212–215 73.93
Z3 1H-Benzo[d]imidazol-2-yl 2-(3-nitrophenylamino)ethanethioate C15H12N4O3S 0.75 217–220 85.74
Z4 1H-Benzo[d]imidazol-2-yl 2-(3-bromophenylamino)ethanethioate C15H12N3OSBr 0.47 257–260 73.19
Z5 1H-Benzo[d]imidazol-2-yl 2-(4-bromophenylamino)ethanethioate C15H12N3OSBr 0.65 260–263 57.48
Z6 1H-Benzo[d]imidazol-2-yl 2-(4-chloro-2-nitrophenylamino) ethanethioate C15H11N4O3SCl 0.66 140–143 94.19
Z7 1H-Benzo[d]imidazol-2-yl 2-(2-chlorophenylamino)ethanethioate C15H12N3OSCl 0.60 277–280 60.63
Z8 1H-Benzo[d]imidazol-2-yl 2-(3-chlorophenylamino)ethanethioate C15H12N3OSCl 0.68 265–268 65.87
Z9 1H-Benzo[d]imidazol-2-yl 2-(2,6-dimethyyphenylamino) ethanethioate C17H17N3OS 0.59 274–277 65.52
Z10 1H-Benzo[d]imidazol-2-yl 2-(2-chloro-4-nitrophenylamino) ethanethioate C15H11N4O3SCl 0.74 180–183 91.45
Z11 1H-Benzo[d]imidazol-2-yl 2-(2-florophenylamino)ethanethioate C15H12N3OSF 0.73 272–275 72.43
Z12 1H-Benzo[d]imidazol-2-yl 2-(4-florophenylamino)ethanethioate C15H12N3OSF 0.55 270–273 68.60
Z13 1H-Benzo[d]imidazol-2-yl 2-(4-methylphenylamino)ethanethioate C16H15N3OS 0.61 266–269 64.13
Z14 1H-Benzo[d]imidazol-2-yl 2 (methyl (phenyl)amino)ethanethioate C17H17N3OS 0.70 245–248 53.40
Z15 H-Benzo[d]imidazol-2-yl 2-(ethy l(phenyl)amino)ethanethioate C16H15N3OS 0.75 261–264 56.95
Z16 1H-Benzo[d]imidazol-2-yl 2-(2-(2-nitrobenzylidene)hydrazinyl) ethanethioate C16H13N5O3S 0.58 258–260 59.40
Z17 1H-Benzo[d]imidazol-2-yl 2-(2-(3-nitrobenzylidene)hydrazinyl) ethanethioate C16H13N5O3S 0.54 262–265 82.89
Z18 1H-Benzo[d]imidazol-2-yl 2-(2-(4-nitrobenzylidene)hydrazinyl) ethanethioate C16H13N5O3S 0.59 250–253 65.04
Z19 1H-Benzo[d]imidazol-2-yl 2-(2-(4-hydroxy-3-methoxybenzylidene) hydrazinyl)ethanethioate C17H16N4O3S 0.53 263–266 53.93
Z20 1H-Benzo[d]imidazol-2-yl 2-(2-(3-ethoxy-4-hydoxybenzylidene) hydrazinyl)ethanethioate C18H18N4O3S 0.52 269–272 60.65
Z21 1H-Benzo[d]imidazol-2-yl 2-(2-(4-bromobenzylidene)hydrazinyl) ethanethioate C16H13N4OSBr 0.50 277–280 65.52
Z22 1H-Benzo[d]imidazol-2-yl 2-(2-(2-hydroxybenzylidene)hydrazinyl) ethanethioate C16H14N4O2S 0.57 259–262 63.60
Z23 1H-Benzo[d]imidazol-2-yl 2-(2-(3,4-dimethoxybenzylidene) hydrazinyl)ethanethioate C18H18N4O3S 0.46 264–267 72.30
Z24 1H-Benzo[d]imidazol-2-yl 2-(2-(2-bromo-3-phenylallylidene) hydrazinyl)ethanethioate C18H15N4OSBr 0.51 160–163 78.68
Z25 1H-Benzo[d]imidazol-2-yl 2-(2-(4-(dimethylamino)benzylidene) hydrazinyl)ethanethioate C17H14N4O2S 0.57 250–253 72.58
Z26 1H-Benzo[d]imidazol-2-yl 2-(2-(4-formylbenzylidene) hydrazinyl)ethanethioate C18H19N5OS 0.65 200–203 87.45
Z27 1H-Benzo[d]imidazol-2-yl 2-(2-(2,4-dichlorobenzylidene) hydrazinyl) ethanethioate C16H12N4OSCl2 0.49 255–257 81.69
Z28 1H-Benzo[d]imidazol-2-yl 2-(2-(2-chlorobenzylidene)hydrazinyl) ethanethioate C16H13N4OSCl 0.64 259–262 74.33
Z29 1H-Benzo[d]imidazol-2-yl 2-(2-(3-phenylallylidene)hydrazinyl) ethanethioate C18H16N4OS 0.56 264–267 64.68
Z30 1H-Benzo[d]imidazol-2-yl 2-(2-(2-methoxylbenzylidene) hydrazinyl)ethanethioate C17H16N4O2S 0.48 267–270 57.12
  1. aTLC mobile phase-ethyl acetate