Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents

Table 3 Docking results of most active antibacterial compounds (d1, d2 and d3) with standard drug

Compounds	Docking score	Glide energy (kcal/mol)	Interacting amino acid residues
d1	− 5.126	− 62.761	Asp40, Ala39, Gly38, Tyr36, Tyr170, Thr75, Asn124, Gly72, Leu70
d2	− 5.403	− 58.496	Thr42, Asp40, Ala39, Gly38, Cys37, Tyr36, Gln190, Val191, Gln192, Gly193, Hie50
d3	− 4.806	− 55.908	Tyr36, Gly38, Ala39, Asp40, Pro53, Hie50, Gly49, Gln190, Gly193, Asp195, Gln196
Norfloxacin	− 6.18	− 53.349	Asp177, Glu174, Leu70, Tyr36, Cys37, Gly38, Ala39, Asp40, Gln190, Val191, Gly192

ISSN: 2661-801X