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Table 2 Antimicrobial and anticancer activities of synthesized compounds (d1–d9)

From: Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents

Compounds

Antimicrobial Screening (MIC = µM)

*IC50 = µM

Microbial species

Bacterial

Fungal

Cancer cell line

S.A.

B.S.

E.C.

C.A.

A.N.

MCF7

d1

26.7

53.5

26.7

26.7

26.7

55.6

d2

26.7

26.7

26.7

13.4

26.7

76.9

d3

13.4

26.8

53.5

26.8

13.4

171.3

d4

14.4

28.8

28.8

28.8

28.8

101.6

d5

15.3

30.7

30.7

30.7

30.7

132.6

d6

27.9

27.9

27.9

14.0

27.9

38.0

d7

29.9

29.9

59.8

14.9

29.9

40.6

d8

13.8

27.6

27.6

27.6

27.6

44.2

d9

28.9

28.9

28.9

14.5

28.9

76.3

Norfloxacin

4.7

4.7

4.7

–

–

–

Fluconazole

–

–

–

5.0

5.0

–

5-Fluorouracil

–

–

–

–

–

5.2

  1. *IC50 is the concentration required to kill 50% of cell population
  2. S.A., Staphylococcus aureus (MTCC3160); B.S., Bacillus subtilis (MTCC441); E.C., Escherichia coli (MTCC443); C.A., Candida albicans (MTCC227); A.N., Aspergillus niger (MTCC281)