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Table 2 In-vitro DPPH radical scavenging activities and IC50 of synthesized morin derivatives (antioxidant activity)

From: Molecular docking, synthesis, kinetics study, structure–activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors

Compound

IC50 (µM)a

Compound

IC50 (µM)a

M2a

7.795 ± 0.003

M2i

7.73 ± 0.015

M2b

7.37 ± 0.024

M3

11.9 ± 0.031

M2c

10.18 ± 0.006

M4

8.099 ± 0.018

M2d

11.56 ± 0.013

M5

8.78 ± 0.008

M2e

8.744 ± 0.008

M6

9.65 ± 0.022

M2f

10.50 ± 0.036

Morin

12.83 ± 0.028

M2g

10.66 ± 0.019

Ascorbic acid

8.59 ± 0.004

M2h

9.290 ± 0.007

  
  1. aValues related for the evaluated compound absorption which provide 50% inhibition of Urease inhibition action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against urease, as identified through ANOVA/Dunnett’s test
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BMC Chemistry

ISSN: 2661-801X

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