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Table 1 In-vitro urease inhibition activity and IC50 of synthesized morin derivatives

From: Molecular docking, synthesis, kinetics study, structure–activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors

Compound

IC50(µM)a

Compound

IC50(µM)a

M2a

12.71 ± 0.027

M2i

11.12 ± 0.033

M2b

10.74 ± 0.018

M3

17.9 ± 0.007

M2c

19.5 ± 0.005

M4

18.96 ± 0.011

M2d

20.41 ± 0.031

M5

17.68 ± 0.08

M2e

20.2 ± 0.01

M6

17.66 ± 0.02

M2f

19.06 ± 0.015

Morin

21.77 ± 0.016

M2g

20.48 ± 0.026

Thiourea

22.80 ± 0.011

M2h

16.55 ± 0.011

  
  1. aValues related for the evaluated compound absorption which provide 50% inhibition of Urease inhibition action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against urease, as identified through ANOVA/Dunnett’s test
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BMC Chemistry

ISSN: 2661-801X

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