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Table 1 Inhibitory activities and binding energies of docked 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine derivatives and acarbose into the active site of α-glucosidase

From: Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors

Name of synthesized derivatives Free binding energy (kcal/mol) Number of hydrogen bonds Number of closest residues
2a − 8.12 1 10
3 − 9.17 3 6
6a − 9.76 1 7
6b − 9.42 3 9
6d − 9.64 3 8
6h − 10.55 3 7
Acarbose − 10.56 10 10