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Table 2 IC50 value synthesized compounds for urease inhibition and antioxidant activity

From: In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

Compound IC50 (µM) urease inhibitiona IC50 (µM) antioxidant activitya
C4a 11.01 ± 0.013 5.10 ± 0.018
C4b 15.86 ± 0.004 6.01 ± 0.005
C4c 22.02 ± 0.027 8.48 ± 0.026
C4d 13.8 ± 0.041 5.34 ± 0.007
C4e 20.6 ± 0.001 6.85 ± 0.020
C4f 21.83 ± 0.009 7.89 ± 0.006
C4g 21.5 ± 0.032 7.75 ± 0.011
C4h 21.24 ± 0.016 7.23 ± 0.008
CHLG 22.68 ± 0.006 8.55 ± 0.01
Thiourea 22.80 ± 0.011
Ascorbic acid 8.59 ± 0.004
  1. aValues related for the evaluated compound absorption which provide 50% inhibition of Urease inhibition action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against urease, as identified through ANOVA/Dunnett’s test