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Table 2 IC50 value synthesized compounds for urease inhibition and antioxidant activity

From: In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

Compound

IC50 (µM) urease inhibitiona

IC50 (µM) antioxidant activitya

C4a

11.01 ± 0.013

5.10 ± 0.018

C4b

15.86 ± 0.004

6.01 ± 0.005

C4c

22.02 ± 0.027

8.48 ± 0.026

C4d

13.8 ± 0.041

5.34 ± 0.007

C4e

20.6 ± 0.001

6.85 ± 0.020

C4f

21.83 ± 0.009

7.89 ± 0.006

C4g

21.5 ± 0.032

7.75 ± 0.011

C4h

21.24 ± 0.016

7.23 ± 0.008

CHLG

22.68 ± 0.006

8.55 ± 0.01

Thiourea

22.80 ± 0.011

–

Ascorbic acid

–

8.59 ± 0.004

  1. aValues related for the evaluated compound absorption which provide 50% inhibition of Urease inhibition action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against urease, as identified through ANOVA/Dunnett’s test