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Table 1 Optimization of the synthesis of dispiropyrolothiazole 4a

From: An expeditious and environmentally benign synthesis of dispiro-3-phenylpyrrolothiazoles in ACI/EG eutectic mixture and its antioxidant and antimicrobial activities against urinary tract pathogens

Entry

Solvent

Time (h)

Yield (%)

RT

50 °C

1

[Bmim][OH]

4

25

45

2

[Bmim][Br]

4

30

48

3

[Bmim][Cl]

4

30

46

4

[Bmim][BF4]

4

32

46

5

[Bmim][PF6]

4

28

49

6

[Emim][ClO4]

4

32

46

7

[Emim][CF3SO3]

4

46

52

8

[Emim][PF6]

4

38

58

9

[Emim][NO3]

4

30

42

10

ACI/EG

1

78

89