Compound/sample | IC50 (µM)a hMAO-A | IC50 (µM)a hMAO-B | Selectivity indexb | Docking score hMAO-A | Docking score hMAO-B |
---|---|---|---|---|---|
5a | 15.85 ± 0.039 | 29.37 ± 0.048 | 0.53 | − 9.65 | − 3.23 |
5b | 5.989 ± 0.007 | 31.19 ± 0.016 | 0.19 | − 12.57 | − 3.98 |
7 | 10.46 ± 0.072 | 43.31 ± 0.043 | 0.24 | − 11.45 | − 1.76 |
9a | 10.84 ± 0.025 | 47.70 ± 0.073 | 0.22 | − 11.34 | − 1.01 |
9b | 16.62 ± 0.004 | 27.85 ± 0.054 | 0.59 | − 8.99 | − 6.45 |
11 | 18.06 ± 0.044 | 26.80 ± 0.077 | 0.67 | − 7.34 | − 5.34 |
13a | 38.53 ± 0.018 | 7.494 ± 0.014 | 5.14 | − 2.45 | − 11.87 |
13b | 52.55 ± 0.038 | 9.183 ± 0.034 | 5.72 | − 1.09 | − 10.45 |
13c | 22.38 ± 0.067 | 12.66 ± 0.021 | 1.76 | − 6.45 | − 10.32 |
13d | 20.89 ± 0.023 | 13.95 ± 0.005 | 1.49 | − 5.32 | − 9.99 |
16 | 7.348 ± 0.027 | 49.15 ± 0.011 | 0.14 | − 11.98 | − 2.21 |
17 | 13.92 ± 0.051 | 34.20 ± 0.037 | 0.40 | − 9.99 | − 4.23 |
Eugenol | 16.54 ± 0.045 | 13.30 ± 0.037 | 1.24 | − 6.46 | − 7.82 |
Pargyline | – | 20.04 ± 0.095 | – | − 6.061 | – |
Chlorgyline | 18.74 ± 0.096 | – | – | – | − 5.773 |