Table 2 Reported inhibitors of Pfpmt
S. no. | Compound | (µM) PfPMT activity IC50 | (µM) asexual proliferation IC50 |
|---|---|---|---|
1 | NSC 39225 | 2.4 ± 1.5 | 5.6 |
2 | NSC 22225 | 3.1 ± 2.0 | 0.8 ± 1.1 |
3 | NSC 109268 | 3.3 ± 1.3 | 2.7 |
4 | NSC 310551 | 3.5 ± 1.6 | 3.8 ± 1.8 |
5 | NSC 348401 | 3.9 ± 0.3 | 5.2 ± 0.2 |
6 | NSC 641296 | 3.8 ± 0.7 | 3.6 ± 1.2 |
7 | NSC 125034 | 4.3 ± 2.7 | 4.7 |
8 | NSC 668394 | 7.7 ± 4.8 | 1.3 ± 0.4 |
9 | NSC 150080 | 8.5 ± 4.9 | 4.8 |
10 | NSC 158011 | 9.2 ± 3.5 | 5.2 |
11 | NSC 323241 | 9.5 ± 3.4 | 1.1 ± 0.2 |