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Table 2 Reported inhibitors of Pfpmt

From: Docking predictions based Plasmodium falciparum phosphoethanolamine methyl transferase inhibitor identification and in-vitro antimalarial activity analysis

S. no. Compound (µM) PfPMT activity IC50 (µM) asexual proliferation IC50
1 NSC 39225 2.4 ± 1.5 5.6
2 NSC 22225 3.1 ± 2.0 0.8 ± 1.1
3 NSC 109268 3.3 ± 1.3 2.7
4 NSC 310551 3.5 ± 1.6 3.8 ± 1.8
5 NSC 348401 3.9 ± 0.3 5.2 ± 0.2
6 NSC 641296 3.8 ± 0.7 3.6 ± 1.2
7 NSC 125034 4.3 ± 2.7 4.7
8 NSC 668394 7.7 ± 4.8 1.3 ± 0.4
9 NSC 150080 8.5 ± 4.9 4.8
10 NSC 158011 9.2 ± 3.5 5.2
11 NSC 323241 9.5 ± 3.4 1.1 ± 0.2