Compound | R1 | R2 | R3 | –O– | Curative activity(%)a | Protective activity(%)a |
---|---|---|---|---|---|---|
8a | H | Pyridin-2-yl | 3-ClPh | 4-O | 44.6 ± 1.7 | 59.4 ± 1.6 |
8b | H | Pyridin-2-yl | 3-MePh | 4-O | 40.1 ± 2.4 | 56.4 ± 1.3 |
8c | H | Pyridin-2-yl | 2-ClPh | 4-O | 55.9 ± 2.9 | 69.8 ± 5.8 |
8d | H | Pyridin-2-yl | 4-ClPh | 4-O | 53.4 ± 3.9 | 44.7 ± 3.2 |
8e | H | Pyridin-2-yl | 2,4-di-ClPh | 4-O | 54.6 ± 4.5 | 60.1 ± 3.4 |
8f | Cl | Pyridin-2-yl | 3-MePh | 4-O | 31.7 ± 3.8 | 39.4 ± 4.0 |
8g | Cl | Pyridin-2-yl | 3-ClPh | 4-O | 33.4 ± 5.6 | 55.4 ± 4.9 |
8h | Cl | Pyridin-2-yl | 2-ClPh | 4-O | 44.9 ± 4.7 | 52.1 ± 4.1 |
8i | Cl | Pyridin-2-yl | 4-ClPh | 4-O | 45.3 ± 4.8 | 47.7 ± 6.3 |
8j | H | Pyridin-2-yl | 2-ClPh | 2-O | 55.4 ± 4.3 | 67.7 ± 1.7 |
8k | H | Pyridin-2-yl | 2,4-di-ClPh | 2-O | 59.1 ± 4.2 | 72.0 ± 3.9 |
8l | Cl | Pyridin-2-yl | 2-ClPh | 2-O | 45.8 ± 6.1 | 48.9 ± 4.3 |
8m | Cl | Pyridin-2-yl | 2,4-di-ClPh | 2-O | 50.5 ± 4.9 | 54.4 ± 3.9 |
8n | H | Thiophene-2-yl | 2,4-di-ClPh | 4-O | 37.3 ± 6.1 | 50.3 ± 5.1 |
8o | H | Pyridin-3-yl | 2-ClPh | 4-O | 53.5 ± 2.5 | 65.1 ± 6.2 |
8p | H | Pyridin-3-yl | 3-MePh | 4-O | 37.4 ± 3.6 | 53.2 ± 3.5 |
Ningnanmycinb | – | – | – | – | 51.8 ± 4.3 | 65.7 ± 2.9 |