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Table 1 Antiviral effects of title compounds against TMV in vivo at 500 μg/mL

From: Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold

Compound R1 R2 R3 –O– Curative activity(%)a Protective activity(%)a
8a H Pyridin-2-yl 3-ClPh 4-O 44.6 ± 1.7 59.4 ± 1.6
8b H Pyridin-2-yl 3-MePh 4-O 40.1 ± 2.4 56.4 ± 1.3
8c H Pyridin-2-yl 2-ClPh 4-O 55.9 ± 2.9 69.8 ± 5.8
8d H Pyridin-2-yl 4-ClPh 4-O 53.4 ± 3.9 44.7 ± 3.2
8e H Pyridin-2-yl 2,4-di-ClPh 4-O 54.6 ± 4.5 60.1 ± 3.4
8f Cl Pyridin-2-yl 3-MePh 4-O 31.7 ± 3.8 39.4 ± 4.0
8g Cl Pyridin-2-yl 3-ClPh 4-O 33.4 ± 5.6 55.4 ± 4.9
8h Cl Pyridin-2-yl 2-ClPh 4-O 44.9 ± 4.7 52.1 ± 4.1
8i Cl Pyridin-2-yl 4-ClPh 4-O 45.3 ± 4.8 47.7 ± 6.3
8j H Pyridin-2-yl 2-ClPh 2-O 55.4 ± 4.3 67.7 ± 1.7
8k H Pyridin-2-yl 2,4-di-ClPh 2-O 59.1 ± 4.2 72.0 ± 3.9
8l Cl Pyridin-2-yl 2-ClPh 2-O 45.8 ± 6.1 48.9 ± 4.3
8m Cl Pyridin-2-yl 2,4-di-ClPh 2-O 50.5 ± 4.9 54.4 ± 3.9
8n H Thiophene-2-yl 2,4-di-ClPh 4-O 37.3 ± 6.1 50.3 ± 5.1
8o H Pyridin-3-yl 2-ClPh 4-O 53.5 ± 2.5 65.1 ± 6.2
8p H Pyridin-3-yl 3-MePh 4-O 37.4 ± 3.6 53.2 ± 3.5
Ningnanmycinb 51.8 ± 4.3 65.7 ± 2.9
  1. aAverage of three replicates
  2. bNingnanmycin was used as a comparision