|
Compounds
|
MIC (minimum inhibitory concentration = µM)
|
IC50 (μM)
|
|---|
|
Bacterial strains
|
Fungal strains
|
Cancer cell line (HCT116)
|
|---|
|
Gram +ve
|
Gram −ve
|
|---|
|
MICbs
|
MICsa
|
MICec
|
MICst
|
MICkp
|
MICca
|
MICan
|
|---|
|
N1
|
1.27
|
5.08
|
5.08
|
2.54
|
5.08
|
1.27
|
5.08
|
> 20.31
|
|
N2
|
1.40
|
5.59
|
5.59
|
2.79
|
5.59
|
2.79
|
2.79
|
> 22.35
|
|
N3
|
1.40
|
5.59
|
2.79
|
2.79
|
5.59
|
2.79
|
2.79
|
> 22.35
|
|
N4
|
1.40
|
5.59
|
2.79
|
2.79
|
2.79
|
2.79
|
2.79
|
> 22.35
|
|
N5
|
2.60
|
5.19
|
2.60
|
2.60
|
5.19
|
2.60
|
5.19
|
> 20.77
|
|
N6
|
1.30
|
5.19
|
2.59
|
2.59
|
5.19
|
2.59
|
2.59
|
> 20.75
|
|
N7
|
1.43
|
5.72
|
5.72
|
2.86
|
2.86
|
2.86
|
2.86
|
> 22.89
|
|
N8
|
1.43
|
5.72
|
1.43
|
2.86
|
2.86
|
2.86
|
2.86
|
13.73
|
|
N9
|
2.90
|
5.81
|
5.81
|
2.90
|
5.81
|
2.90
|
2.90
|
5.85
|
|
N10
|
1.45
|
5.81
|
5.81
|
2.90
|
5.81
|
2.90
|
2.90
|
> 23.23
|
|
N11
|
1.50
|
6.00
|
6.00
|
3.00
|
3.00
|
3.00
|
3.00
|
> 24.01
|
|
N12
|
1.30
|
5.19
|
5.19
|
2.59
|
5.19
|
2.59
|
5.19
|
> 20.75
|
|
N13
|
1.43
|
5.72
|
5.72
|
2.86
|
5.72
|
2.86
|
5.72
|
> 22.89
|
|
N14
|
3.11
|
6.21
|
6.21
|
6.21
|
3.11
|
3.11
|
6.21
|
12.42
|
|
N15
|
1.50
|
6.00
|
6.00
|
3.00
|
3.00
|
3.00
|
6.00
|
19.21
|
|
N16
|
2.89
|
5.78
|
5.78
|
2.89
|
5.78
|
2.89
|
2.89
|
> 23.12
|
|
N17
|
1.45
|
5.78
|
5.78
|
2.89
|
2.89
|
2.89
|
2.89
|
> 23.12
|
|
N18
|
1.45
|
5.78
|
2.89
|
2.89
|
2.89
|
2.89
|
5.78
|
4.53
|
|
N19
|
1.49
|
5.95
|
5.95
|
5.95
|
2.97
|
2.97
|
5.95
|
> 23.78
|
|
N20
|
2.97
|
5.95
|
5.95
|
5.95
|
5.95
|
2.97
|
2.97
|
14.27
|
|
N21
|
2.90
|
5.81
|
2.90
|
5.81
|
2.90
|
2.90
|
2.90
|
> 23.23
|
|
N22
|
1.30
|
5.19
|
2.60
|
2.60
|
2.60
|
2.60
|
2.60
|
> 13.86
|
|
N23
|
2.65
|
2.65
|
2.65
|
2.65
|
2.65
|
2.65
|
2.65
|
> 21.22
|
|
N24
|
1.50
|
6.00
|
3.00
|
3.00
|
3.00
|
3.00
|
3.00
|
20.41
|
|
N25
|
2.65
|
2.65
|
2.65
|
2.65
|
5.30
|
2.65
|
2.65
|
> 21.22
|
|
N26
|
1.31
|
5.22
|
2.61
|
2.61
|
5.22
|
2.61
|
2.61
|
> 20.90
|
|
Broth control
|
NG
|
NG
|
NG
|
NG
|
NG
|
NG
|
NG
|
–
|
|
Std.
|
1.72a
|
3.44a
|
3.44a
|
3.44a
|
3.44a
|
4.08b
|
4.08b
|
9.99c
|
- Bacillus subtilis MTCC 441-bs, Staphylococcus aureus MTCC 3160-sa, Escherichia coli MTCC 443-ec, Salmonella typhi MTCC 3231-st, Klebsiella pneumoniae MTCC 9024-kp, Candida albicans MTCC 227-ca and Aspergillus niger MTCC 281-an
- DMSO dimethyl sulfoxide, NG no growth
- Std. drugs: a Cefadroxil; b Fluconazole; c 5-FU (5-Fluorouracil)
