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Table 3 Antimicrobial and anticancer screening results of synthesized compounds

From: 4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

Compounds

MIC (minimum inhibitory concentration = µM)

IC50 (μM)

Bacterial strains

Fungal strains

Cancer cell line (HCT116)

Gram +ve

Gram −ve

MICbs

MICsa

MICec

MICst

MICkp

MICca

MICan

N1

1.27

5.08

5.08

2.54

5.08

1.27

5.08

> 20.31

N2

1.40

5.59

5.59

2.79

5.59

2.79

2.79

> 22.35

N3

1.40

5.59

2.79

2.79

5.59

2.79

2.79

> 22.35

N4

1.40

5.59

2.79

2.79

2.79

2.79

2.79

> 22.35

N5

2.60

5.19

2.60

2.60

5.19

2.60

5.19

> 20.77

N6

1.30

5.19

2.59

2.59

5.19

2.59

2.59

> 20.75

N7

1.43

5.72

5.72

2.86

2.86

2.86

2.86

> 22.89

N8

1.43

5.72

1.43

2.86

2.86

2.86

2.86

13.73

N9

2.90

5.81

5.81

2.90

5.81

2.90

2.90

5.85

N10

1.45

5.81

5.81

2.90

5.81

2.90

2.90

> 23.23

N11

1.50

6.00

6.00

3.00

3.00

3.00

3.00

> 24.01

N12

1.30

5.19

5.19

2.59

5.19

2.59

5.19

> 20.75

N13

1.43

5.72

5.72

2.86

5.72

2.86

5.72

> 22.89

N14

3.11

6.21

6.21

6.21

3.11

3.11

6.21

12.42

N15

1.50

6.00

6.00

3.00

3.00

3.00

6.00

19.21

N16

2.89

5.78

5.78

2.89

5.78

2.89

2.89

> 23.12

N17

1.45

5.78

5.78

2.89

2.89

2.89

2.89

> 23.12

N18

1.45

5.78

2.89

2.89

2.89

2.89

5.78

4.53

N19

1.49

5.95

5.95

5.95

2.97

2.97

5.95

> 23.78

N20

2.97

5.95

5.95

5.95

5.95

2.97

2.97

14.27

N21

2.90

5.81

2.90

5.81

2.90

2.90

2.90

> 23.23

N22

1.30

5.19

2.60

2.60

2.60

2.60

2.60

> 13.86

N23

2.65

2.65

2.65

2.65

2.65

2.65

2.65

> 21.22

N24

1.50

6.00

3.00

3.00

3.00

3.00

3.00

20.41

N25

2.65

2.65

2.65

2.65

5.30

2.65

2.65

> 21.22

N26

1.31

5.22

2.61

2.61

5.22

2.61

2.61

> 20.90

Broth control

NG

NG

NG

NG

NG

NG

NG

Std.

1.72a

3.44a

3.44a

3.44a

3.44a

4.08b

4.08b

9.99c

  1. Bacillus subtilis MTCC 441-bs, Staphylococcus aureus MTCC 3160-sa, Escherichia coli MTCC 443-ec, Salmonella typhi MTCC 3231-st, Klebsiella pneumoniae MTCC 9024-kp, Candida albicans MTCC 227-ca and Aspergillus niger MTCC 281-an
  2. DMSO dimethyl sulfoxide, NG no growth
  3. Std. drugs: a Cefadroxil; b Fluconazole; c 5-FU (5-Fluorouracil)