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Table 3 Antimicrobial and anticancer screening results of synthesized compounds

From: 4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

Compounds MIC (minimum inhibitory concentration = µM) IC50 (μM)
Bacterial strains Fungal strains Cancer cell line (HCT116)
Gram +ve Gram −ve
MICbs MICsa MICec MICst MICkp MICca MICan
N1 1.27 5.08 5.08 2.54 5.08 1.27 5.08 > 20.31
N2 1.40 5.59 5.59 2.79 5.59 2.79 2.79 > 22.35
N3 1.40 5.59 2.79 2.79 5.59 2.79 2.79 > 22.35
N4 1.40 5.59 2.79 2.79 2.79 2.79 2.79 > 22.35
N5 2.60 5.19 2.60 2.60 5.19 2.60 5.19 > 20.77
N6 1.30 5.19 2.59 2.59 5.19 2.59 2.59 > 20.75
N7 1.43 5.72 5.72 2.86 2.86 2.86 2.86 > 22.89
N8 1.43 5.72 1.43 2.86 2.86 2.86 2.86 13.73
N9 2.90 5.81 5.81 2.90 5.81 2.90 2.90 5.85
N10 1.45 5.81 5.81 2.90 5.81 2.90 2.90 > 23.23
N11 1.50 6.00 6.00 3.00 3.00 3.00 3.00 > 24.01
N12 1.30 5.19 5.19 2.59 5.19 2.59 5.19 > 20.75
N13 1.43 5.72 5.72 2.86 5.72 2.86 5.72 > 22.89
N14 3.11 6.21 6.21 6.21 3.11 3.11 6.21 12.42
N15 1.50 6.00 6.00 3.00 3.00 3.00 6.00 19.21
N16 2.89 5.78 5.78 2.89 5.78 2.89 2.89 > 23.12
N17 1.45 5.78 5.78 2.89 2.89 2.89 2.89 > 23.12
N18 1.45 5.78 2.89 2.89 2.89 2.89 5.78 4.53
N19 1.49 5.95 5.95 5.95 2.97 2.97 5.95 > 23.78
N20 2.97 5.95 5.95 5.95 5.95 2.97 2.97 14.27
N21 2.90 5.81 2.90 5.81 2.90 2.90 2.90 > 23.23
N22 1.30 5.19 2.60 2.60 2.60 2.60 2.60 > 13.86
N23 2.65 2.65 2.65 2.65 2.65 2.65 2.65 > 21.22
N24 1.50 6.00 3.00 3.00 3.00 3.00 3.00 20.41
N25 2.65 2.65 2.65 2.65 5.30 2.65 2.65 > 21.22
N26 1.31 5.22 2.61 2.61 5.22 2.61 2.61 > 20.90
Broth control NG NG NG NG NG NG NG
Std. 1.72a 3.44a 3.44a 3.44a 3.44a 4.08b 4.08b 9.99c
  1. Bacillus subtilis MTCC 441-bs, Staphylococcus aureus MTCC 3160-sa, Escherichia coli MTCC 443-ec, Salmonella typhi MTCC 3231-st, Klebsiella pneumoniae MTCC 9024-kp, Candida albicans MTCC 227-ca and Aspergillus niger MTCC 281-an
  2. DMSO dimethyl sulfoxide, NG no growth
  3. Std. drugs: a Cefadroxil; b Fluconazole; c 5-FU (5-Fluorouracil)