Synthetic route followed for 3,5-disubstituted benzamide derivatives. Reagents and conditions: (a) chlorosulphonic acid, 80 °C, 2 h; (b) NH2-R, chloroform, reflux; c thionyl chloride, chloroform, reflux; (d) 2-aminopyrimidine, chloroform, reflux; (e) 2-aminothiazole, chloroform, reflux