Table 15 Antimycobacterial screening results of compound 18a (MIC = µmol/L)
From: Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review
Compound | Bacterial strains | Fungal strains | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M. tuberculosis MY 331/88 | M. kansasii My 235/80 | M. kansasii My 6509/96 | M. avium (M. My 330/88) | T. mentagrophytes 445 | A. corymbifera 272 | A. fumigates 231 | |||||||
14Â days | 21Â days | 7Â days | 14Â days | 21Â days | 7Â days | 14Â days | 21Â days | 14Â days | 21Â days | 72Â h | 24Â h | 24Â h | |
18a | 4 | 4 | 4 | 8 | 8 | 4 | 8 | 8 | 8 | 8 | 62 | – | – |
Isoniazide | 0.5 | 1 | > 250 | > 250 | > 250 | 2 | 4 | 4 | > 250 | > 250 | – | – | – |
Ketoconazole | – | – | – | – | – | – | – | – | – | – | 0.98 | 31.25 | 7.81 |