Table 15 Antimycobacterial screening results of compound 18a (MIC = µmol/L)
From: Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review
| Compound | Bacterial strains | Fungal strains | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
M. tuberculosis
MY 331/88 |
M. kansasii
My 235/80 |
M. kansasii
My 6509/96 |
M. avium
(M. My 330/88) | T. mentagrophytes 445 | A. corymbifera 272 | A. fumigates 231 | |||||||
| 14 days | 21 days | 7 days | 14 days | 21 days | 7 days | 14 days | 21 days | 14 days | 21 days | 72 h | 24 h | 24 h | |
| 18a | 4 | 4 | 4 | 8 | 8 | 4 | 8 | 8 | 8 | 8 | 62 | – | – |
| Isoniazide | 0.5 | 1 | > 250 | > 250 | > 250 | 2 | 4 | 4 | > 250 | > 250 | – | – | – |
| Ketoconazole | – | – | – | – | – | – | – | – | – | – | 0.98 | 31.25 | 7.81 |