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Table 2 Docking results of A3 and B2 with COX-1, COX-2 and human capsaicin receptor

From: Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives

Protein targets Ligand Binding energy Kcal/mol
Cyclooxygenase-1 COX-1, PDB-ID: 3N8X A3 − 8.6
B2 − 7.9
Cyclooxygenase-2 COX-2, PDB-ID: 1PXX A3 − 8.8
B2 − 8.4
Human capsaicin receptor (HCR), PDB-ID: 3J9J A3 − 7.5
B3 − 8.2