Table 25 Activity against metrazol convulsions for the compounds (114a, b, c), (115a, b, c, d, e), and diazepam
Compound | Activity against metrazol convulsions* (ED50, mg/kg) |
|---|---|
114a | 56.0 (36.0–100.8) |
114b | 40.0 (23.5–68.0) |
114c | 23.0 (15.9–33.1) |
115a | 40.0 (23.5–68.0) |
115b | 56.0 (36.0–100.8) |
115c | 34.0 (25.3–45.7) |
115d | 40.0 (23.5–68.0) |
115e | 56.0 (36.0–100.8) |
Diazepam | 0.51 (0.39–0.69) |