Skip to main content

Advertisement

Table 25 Activity against metrazol convulsions for the compounds (114a, b, c), (115a, b, c, d, e), and diazepam

From: Therapeutic importance of synthetic thiophene

Compound Activity against metrazol convulsions* (ED50, mg/kg)
114a 56.0 (36.0–100.8)
114b 40.0 (23.5–68.0)
114c 23.0 (15.9–33.1)
115a 40.0 (23.5–68.0)
115b 56.0 (36.0–100.8)
115c 34.0 (25.3–45.7)
115d 40.0 (23.5–68.0)
115e 56.0 (36.0–100.8)
Diazepam 0.51 (0.39–0.69)
  1. * Probability levels at p = 0.05 are indicated in brackets