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Table 21 Anti-inflammatory activity of the synthesized compounds

From: Therapeutic importance of synthetic thiophene

Compounds

Edema inhibition (means ± E.M)a,b (%)

1 h

2 h

3 h

94

42.3 ± 1.1

49.2 ± 1.2

57.1 ± 1.4

95

37.2 ± 1.3

46.3 ± 1.5

54.4 ± 1.1

96

34.5 ± 1.2

35.1 ± 1.5

48.2 ± 1.2

97

31.2 ± 1.2

35.1 ± 1.5

40.2 ± 1.6

98

39.1 ± 1.5

48.4 ± 1.2

55.6 ± 1.1

Indomethacin

44.7 ± 1.2

52.4 ± 1.2

61.2 ± 1.3

  1. aDose 5 mg/kg b.m (p.o.)
  2. b n = 6