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Table 18 Antiproliferative activity GI50 (μM) of the synthesized compounds

From: Therapeutic importance of synthetic thiophene

Compound GI50 (μM)a
MCF-7 NCI-H460 SF-268
85 10.8 ± 0.6 16.5 ± 0.8 16.7 ± 1.6
86 2.5 ± 0.5 10.4 ± 0.6 8.0 ± 0.4
87 16.7 ± 1.6 10.8 ± 0.6 16.5 ± 0.8
88 11.8 ± 0.6 14.5 ± 0.8 16.7 ± 1.6
89 2.0 ± 0.4 8.3 ± 0.8 4.0 ± 0.8
Doxorubicin 0.0428 ± 0.0082 0.0940 ± 0.0087 0.0940 ± 0.0070
  1. aDrug concentration required to inhibit tumor cell proliferation by 50% after continuous exposure of 48 h. Doxorubicin was used as positive control