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Table 18 Antiproliferative activity GI50 (μM) of the synthesized compounds

From: Therapeutic importance of synthetic thiophene

Compound

GI50 (μM)a

MCF-7

NCI-H460

SF-268

85

10.8 ± 0.6

16.5 ± 0.8

16.7 ± 1.6

86

2.5 ± 0.5

10.4 ± 0.6

8.0 ± 0.4

87

16.7 ± 1.6

10.8 ± 0.6

16.5 ± 0.8

88

11.8 ± 0.6

14.5 ± 0.8

16.7 ± 1.6

89

2.0 ± 0.4

8.3 ± 0.8

4.0 ± 0.8

Doxorubicin

0.0428 ± 0.0082

0.0940 ± 0.0087

0.0940 ± 0.0070

  1. aDrug concentration required to inhibit tumor cell proliferation by 50% after continuous exposure of 48 h. Doxorubicin was used as positive control
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BMC Chemistry

ISSN: 2661-801X

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