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Table 17 Tricyclic compound-induced inhibition of HCT116 growth

From: Therapeutic importance of synthetic thiophene

Time (h)

Compd

0.1 µM

1 µM

10 µM

100 µM

24

83

96.1 ± 3.8

106.6 ± 4.8

104.8 ± 3.8

82.0 ± 7.8

48

83

105.1 ± 3.3

98.3 ± 4.3

105.0 ± 2.1

71.5 ± 3.8b

72

83

101.3 ± 7.3

96.1 ± 6.6

93.8 ± 12.1

51.5 ± 10.7a

  1. HCT116 cells were treated and growth was assessed. Data represent the average (SEM as a % of control-treated (DMSO) cells (n = 3–5)
  2. ap < 0.05
  3. bp < 0.005 when compared to control-treated cells
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BMC Chemistry

ISSN: 2661-801X

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