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Table 17 Tricyclic compound-induced inhibition of HCT116 growth

From: Therapeutic importance of synthetic thiophene

Time (h) Compd 0.1 µM 1 µM 10 µM 100 µM
24 83 96.1 ± 3.8 106.6 ± 4.8 104.8 ± 3.8 82.0 ± 7.8
48 83 105.1 ± 3.3 98.3 ± 4.3 105.0 ± 2.1 71.5 ± 3.8b
72 83 101.3 ± 7.3 96.1 ± 6.6 93.8 ± 12.1 51.5 ± 10.7a
  1. HCT116 cells were treated and growth was assessed. Data represent the average (SEM as a % of control-treated (DMSO) cells (n = 3–5)
  2. ap < 0.05
  3. bp < 0.005 when compared to control-treated cells