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Table 15 Anticancer activity of the title compounds

From: Therapeutic importance of synthetic thiophene

Compound IC50 (μmol/l)a
MCF-7 NCI-H460 SF-268 WI-38
74 0.03 ± 0.007 0.02 ± 0.008 0.01 ± 0.004 > 100
76b 0.01 ± 0.006 0.03 ± 0.002 0.06 ± 0.005 > 100
77 0.01 ± 0.003 0.02 ± 0.001 0.01 ± 0.001 66.5 ± 12.7
DSMO 94.3 ± 6.4 96.4 ± 10.2 98.6 ± 12.2 > 100
Doxorubicin 0.0428 ± 0.0082 0.0940 ± 0.0087 0.0940 ± 0.0070 > 100
  1. aDrug concentration required to inhibit tumor cell proliferation by 50% after continuous exposure of 48 h; data are expressed as mean ± SEM of three independent experiments performed in duplicates