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Table 15 Anticancer activity of the title compounds

From: Therapeutic importance of synthetic thiophene

Compound

IC50 (μmol/l)a

MCF-7

NCI-H460

SF-268

WI-38

74

0.03 ± 0.007

0.02 ± 0.008

0.01 ± 0.004

> 100

76b

0.01 ± 0.006

0.03 ± 0.002

0.06 ± 0.005

> 100

77

0.01 ± 0.003

0.02 ± 0.001

0.01 ± 0.001

66.5 ± 12.7

DSMO

94.3 ± 6.4

96.4 ± 10.2

98.6 ± 12.2

> 100

Doxorubicin

0.0428 ± 0.0082

0.0940 ± 0.0087

0.0940 ± 0.0070

> 100

  1. aDrug concentration required to inhibit tumor cell proliferation by 50% after continuous exposure of 48 h; data are expressed as mean ± SEM of three independent experiments performed in duplicates