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Table 13 In vitro anticancer screening of the newly synthesized compounds against the human breast cancer cell line MCF7

From: Therapeutic importance of synthetic thiophene

Compound

Compound concentration (μmol/l)

Surviving fractiona

10

25

50

100

IC50 (μmol/l)

Doxorubicin

0.551 ± 0.026

0.480 ± 0.003

0.139 ± 0.005

0.130 ± 0.016

32.00

59

0.541 ± 0.003

0.323 ± 0.020

0.360 ± 0.018

0.460 ± 0.015

10.25

60

0.480 ± 0.010

0.327 ± 0.016

0.313 ± 0.005

0.381 ± 0.007

9.70

61

0.443 ± 0.017

0.251 ± 0.012

0.355 ± 0.020

0.290 ± 0.009

9.55

62

0.435 ± 0.009

0.233 ± 0.006

0.371 ± 0.018

0.309 ± 0.011

9.39

  1. aMean ± S.E, n = 3