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Table 13 In vitro anticancer screening of the newly synthesized compounds against the human breast cancer cell line MCF7

From: Therapeutic importance of synthetic thiophene

Compound Compound concentration (μmol/l)
Surviving fractiona
10 25 50 100 IC50 (μmol/l)
Doxorubicin 0.551 ± 0.026 0.480 ± 0.003 0.139 ± 0.005 0.130 ± 0.016 32.00
59 0.541 ± 0.003 0.323 ± 0.020 0.360 ± 0.018 0.460 ± 0.015 10.25
60 0.480 ± 0.010 0.327 ± 0.016 0.313 ± 0.005 0.381 ± 0.007 9.70
61 0.443 ± 0.017 0.251 ± 0.012 0.355 ± 0.020 0.290 ± 0.009 9.55
62 0.435 ± 0.009 0.233 ± 0.006 0.371 ± 0.018 0.309 ± 0.011 9.39
  1. aMean ± S.E, n = 3