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Table 6 Statistical parameters of developed CoMSIA model for glucose uptakeactivity

From: Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies

Statistics

Glucose uptake activity

Grid spacing (Å)

2.0

q2 (LOO)

0.712

r2

0.889

S

0.211

F

121

No. of components

6

Contribution of-

 

Steric

0.080

Electrostatic

0.062

Hydrophobic

0.322

Hydrogen bond donor

0.234

Hydrogen bond acceptor

0.302

  1. q2: cross-validated correlation coefficient
  2. r2: non-cross-validated correlation coefficient
  3. S: standard error of estimation; F: Fischer’s covariance ratio
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BMC Chemistry

ISSN: 2661-801X

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